Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 ml
Amount Per Serving
%DV
Vitamin B1 (as thiamine HCl)
4 mg
333%
Riboflavin (as riboflavin 5'-phosphate sodium)
4 mg
308%
Niacin (as niacinamide)
20 mg
125%
Vitamin B6 (as pyridoxine HCl)
10 mg
588%
Folate
333 mcg DFE(200 mcg folic acid)
83%
Vitamin B12 (as cyanocobalamin)
2,000 mcg
83,333%
Biotin
300 mcg
1,000%
Pantothenic Acid (as dexpanthenol)
30 mg
600%
Top Medical Research Studies
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
Read More
8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Read More
8
We explored a compelling case of pernicious anemia that led to a rare presentation of disseminated intravascular coagulation (DIC). The patient, a 63-year-old woman, faced severe anemia and a significant vitamin B12 deficiency.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
Read More
Most Useful Reviews
8
Effective treatment
2 people found this helpful
Excellent! I have taken this in the past and noticed good results in my blood tests, which indicates that it is effective.
Read More
9
Quick absorption
1 people found this helpful
This is an excellent product! The B12 liquid is swiftly absorbed by the body. After using it, my blood test showed a high level of vitamin B12. I have no doubt that it works for me.
Read More
7.5
Reduced fatigue
I've been taking B12 for the past two months after a blood test revealed my deficiency. It was recommended by my functional medicine practitioner, and I can honestly say it's working – I feel less tired than before.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
- All Researches
9
This case report examined a 14-year-old girl who experienced cerebral venous thrombosis alongside high homocysteine levels due to a unique genetic mutation at the MTHFR locus.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
Read More
9
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
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9
We explored how elevated homocysteine levels, termed hyperhomocysteinemia (HHcy), impact patients with acute brain injuries in neurocritical care. Our systematic review of 33 studies revealed that HHcy is an independent risk factor for various brain injuries and a marker of poor prognosis.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Read More
8
We examined a case involving Biermer's disease, where a 56-year-old man experienced neurological and cardiovascular complications. Despite the serious symptoms of melena, memory issues, and swelling in the leg, he was diagnosed with deep vein thrombosis and severe vitamin B12 deficiency.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
Read More
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Effective treatment
2 people found this helpful
Excellent! I have taken this in the past and noticed good results in my blood tests, which indicates that it is effective.
Read More
9
Quick absorption
1 people found this helpful
This is an excellent product! The B12 liquid is swiftly absorbed by the body. After using it, my blood test showed a high level of vitamin B12. I have no doubt that it works for me.
Read More
7.5
Reduced fatigue
I've been taking B12 for the past two months after a blood test revealed my deficiency. It was recommended by my functional medicine practitioner, and I can honestly say it's working – I feel less tired than before.
Read More
Frequently Asked Questions
8
Effective treatment
2 people found this helpful
Excellent! I have taken this in the past and noticed good results in my blood tests, which indicates that it is effective.
7.5
Reduced fatigue
I've been taking B12 for the past two months after a blood test revealed my deficiency. It was recommended by my functional medicine practitioner, and I can honestly say it's working – I feel less tired than before.
9
Quick absorption
1 people found this helpful
This is an excellent product! The B12 liquid is swiftly absorbed by the body. After using it, my blood test showed a high level of vitamin B12. I have no doubt that it works for me.
7
We observed that a study looked into how vitamin B12, alongside folic acid and vitamin D3, can influence homocysteine levels in Parkinson's disease patients on levodopa treatment. High homocysteine levels are linked to an increased risk of blood clots and cardiovascular issues.
Over six months, participants taking the supplement showed a significant reduction in homocysteine levels. This points towards a potential link between vitamin B12 intake and better blood health, ultimately leading to improved quality of life for those with Parkinson's.
Over six months, participants taking the supplement showed a significant reduction in homocysteine levels. This points towards a potential link between vitamin B12 intake and better blood health, ultimately leading to improved quality of life for those with Parkinson's.
7
We explored the relationship between Vitamin B12 deficiency and cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each presented with headaches, and two experienced visual disturbances, which led to evaluations revealing CVST and high homocysteine levels, a known risk factor for clots. Notably, two patients had very low Vitamin B12 levels. All received anticoagulation treatment along with Vitamin B supplements and showed positive responses, with imaging confirming the resolution of thrombosis in two cases. This suggests an important connection between B12 levels and clot formation, particularly in vegetarians.
7
We explored the effects of nitrous oxide on blood clot formation, particularly in a case involving a 23-year-old who developed deep vein thrombosis and pulmonary embolism after using the drug. The patient exhibited elevated homocysteine levels, a known risk factor for clotting issues.
The study suggests that nitrous oxide hinders methionine synthetase activity, leading to increased homocysteine—potentially causing a higher risk of thrombosis. Treatment included vitamin B12 and anticoagulants to address these complications. Overall, we found that recreational use of nitrous oxide may significantly increase the risk of blood clot formation.
The study suggests that nitrous oxide hinders methionine synthetase activity, leading to increased homocysteine—potentially causing a higher risk of thrombosis. Treatment included vitamin B12 and anticoagulants to address these complications. Overall, we found that recreational use of nitrous oxide may significantly increase the risk of blood clot formation.
8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
8
Cerebral thrombosis and vitamin B12
We explored the rare condition of cerebral venous thrombosis (CVT) occurring along with hyperhomocysteinemia and iron-deficiency anemia related to autoimmune gastritis. This case involved a 47-year-old woman who experienced significant neurological symptoms.
After careful diagnosis and treatment, including anticoagulants and vitamin B12 replacement, we observed a positive outcome with recovery and no lasting neurological issues upon discharge. While this case highlights the importance of vitamin B12 in improving patient health, further studies are necessary to fully understand its effects on blood clots.
After careful diagnosis and treatment, including anticoagulants and vitamin B12 replacement, we observed a positive outcome with recovery and no lasting neurological issues upon discharge. While this case highlights the importance of vitamin B12 in improving patient health, further studies are necessary to fully understand its effects on blood clots.
References
- Bizouard T, Caplette C, Duval D, Savary D, Douillet D. Right iliac deep vein thrombosis and pulmonary embolism associated with recreational nitrous oxide: a case report. Int J Emerg Med. 2024;17:169. doi:10.1186/s12245-024-00689-z
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. doi:10.3390/diagnostics14151609
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. doi:10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. doi:10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. doi:10.7759/cureus.41428
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Coelho T, Freitas A, Carmona Alexandrino H, Pinto S. Roux-en-Y Gastric Bypass Surgery Leading to Postprandial Hypoglycemia: A Case Report. Cureus. 2022;14:e32265. doi:10.7759/cureus.32265
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. doi:10.1177/19714009221147224
- Aboona MB, Rapaich L, Etman A, Thomas SW. A Rare Presentation of Pernicious Anemia Manifesting as Disseminated Intravascular Coagulation. J Med Cases. 2022;13:557. doi:10.14740/jmc4020
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. doi:10.3390/jcm11020394
